Try CrossEntropyLossFlat(axis=1). This loss function should be computed on the channels dimension which should be 1 for the output of your unet NxCxHxW. By default the axis is set to -1. The last dimension is correct for standard image classification models but not for unets.
The sizes or shapes of tensors going into your loss function might not be right. You should be able to print out the values using something like this to do further inspection. If I were to guess your model output # of channels vs target indexes may be off by 1.
Thank you, Mat, for your valuable advice. The error was caused by the presence of missing unique class codes in the Mask from the vocab list, specifically codes 27, 35, 36, 38, and 39. To resolve this, I created a dictionary to map these codes to a sequence of integers starting from 0. Then changed the label_func to take replace original codes. This solution worked perfectly.