Advice on creating an own dataset for segmentation


I would like to build a dataset which I would like to annotate in detail.
I am wondering whether some people here have experiences with good software tools to do so.
Preferably software tools who are a bit user friendly and allow to annotate images to use later for semantic segmentation.

I am not sure if it is important but the images are medical, tif and grayscale.

I have fiddled a bit with QuPath, but to me this was far from the easiest software to use and I it was not clear to me how I could use it well to get good annotations and complete (annotating in detail was not really a problem).

Any advice is appreciated.